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To diagnose such conditions, a physician will use the Rome criteria a set used to classify disorders of gut-brain interaction including abdominal pain, functional constipation and irritable bowel syndrome

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This results in a rapid onset of nicotine's effects, including increased alertness and a sense of relaxation

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Smoking cessation method to control their nicotine intake when quitting smoking

The most significant pathways were alanine, aspartate and glutamate metabolism, nucleotide metabolism and glyoxylate and dicarboxylate metabolism